ALCOHOLIC LIVER DS. & CIRRHOSIS
POSTNECROTIC, POSTVIRAL CIRRHOSIS
* irreversible chronic injury of the hepatic parencyma & include extensive fibrosis in association with the formation of regenerative nodules.
* these feature result from hepatocyte necrosis, collapse of the supporting reticulin network, dostortion of the vascular bed, & nodular regeneration of remaining liver parenchyma.
* loss of functional hepatocellular mass may lead to jaundice, edema, coagulopathy, & a variety of metabolic abnormalities; fibrosis & distorted vasculature lead to portal hypertension & its sequalae(esophageal varix, splenomagaly).
* ascites, & hepatic encephalopathy result from both hepatocellular insufficiency & portal hypertension.